Merck
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33226

Sigma-Aldrich

Glicina

puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

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Sinónimos:
Glicocola, Ácido aminoacético, Ácido aminoetanoico
Fórmula lineal:
NH2CH2COOH
Número de CAS:
56-40-6
Peso molecular:
75.07
Beilstein:
635782
Número de EC:
200-272-2
Número MDL:
MFCD00008131
eCl@ss:
32160406
ID de la sustancia en PubChem:
57648780
NACRES:
NA.21

Agency

USP/NF
reag. Ph. Eur.

Nivel de calidad

200

grado

puriss. p.a.

Análisis

99.7-101% (calc. to the dried substance)

formulario

crystalline powder

technique(s)

IR spectroscopy: suitable

impurezas

≤0.001% heavy metals (as Pb)
≤0.02% ammonium (NH4)
≤0.1% water (Karl Fischer)
≤1.0% ninhydrin-positive substances

residuo de ign.

≤0.05% (as SO4)

pérdida

≤0.5% loss on drying, 105°C, 2 h

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

trazas de anión

chloride (Cl-): ≤30 mg/kg
sulfate (SO42-): ≤20 mg/kg

trazas de catión

Fe: ≤5 mg/kg

idoneidad

in accordance for identity (IR)

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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Este artículo
41022515527G7403
Glycine puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

Sigma-Aldrich

33226

Glycine

Glycine ACS reagent, ≥98.5%

Sigma-Aldrich

410225

Glycine

Glycine meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

Sigma-Aldrich

15527

Glycine

Glycine BioXtra, ≥99% (titration)

Sigma-Aldrich

G7403

Glycine

grade

puriss. p.a.

grade

-

grade

-

grade

-

assay

99.7-101% (calc. to the dried substance)

assay

≥98.5%

assay

99-101% (based on anhydrous substance)

assay

≥99% (titration)

form

crystalline powder

form

crystals, powder or granules

form

crystalline powder

form

powder

technique(s)

IR spectroscopy: suitable

technique(s)

-

technique(s)

IR spectroscopy: suitable

technique(s)

electron microscopy: suitable

impurities

≤0.001% heavy metals (as Pb), ≤0.02% ammonium (NH4), ≤0.1% water (Karl Fischer), ≤1.0% ninhydrin-positive substances

impurities

H2SO4, passes test (darkened), Hydrolyzable subsances, passes test

impurities

hydrolyzable substances, complies, organic volatile impurities, complies (GC), residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% ninhydrin-positive substances

impurities

Insoluble matter, passes filter test

Aplicación

Glycine can be used as:
  • A reactant in the natural soil clay-catalyzed cleavage and polycondensation with pyrogallol.
  • A catalyst in the Knoevenagel reaction between aryl aldehydes and malononitrile to form a C=C bond.
  • A reagent in the metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement.

Acciones bioquímicas o fisiológicas

Neurotransmisor inhibidor de la médula espinal, regulador alostérico de los receptores NMDA.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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T1503
Referencia del producto
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25G
Tamaño del envase/cantidad

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Glycine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

76524

Glycine

Glycine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%

Sigma-Aldrich

G8790

Glycine

Glycine European Pharmacopoeia (EP) Reference Standard

G0450000

Glycine

Glycine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1111

Glycine

Richard A Felix et al.
Brain structure & function, 220(5), 2639-2652 (2014-06-30)
The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
Li-Chun Tu et al.
The EMBO journal, 32(24), 3220-3230 (2013-11-12)
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically disordered polypeptides decorating the NPCs. Major impediments
Suzanne L Grant et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 278-282 (2006-08-08)
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically related neuroactive amino acids in the glutamatergic system: L-serine, L-glutamate, L-glutamine, and glycine. On-column sensitivity was in
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