Merck
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37094

Supelco

Rapamycin

VETRANAL®, analytical standard

Sinónimos:
Sirolimus
Empirical Formula (Hill Notation):
C51H79NO13
Número de CAS:
Peso molecular:
914.17
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.24

Nivel de calidad

100

grado

analytical standard

línea de producto

VETRANAL®

caducidad

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

−20°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

Gene Information

human ... FKBP1A(2280)

Descripción general

Rapamycin is a drug, that is used as an inhibitor of mechanistic target of rapamycin (MTOR), which is a key regulatory protein kinase that controls cytokine-dependent cell proliferation

Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Información legal

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Carc. 2 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 2

Certificado de Análisis

Introduzca el número de lote para buscar un certificado de análisis (COA).

Certificado de origen

Introduzca el número de lote para buscar un Certificado de origen (COO).

Más documentos

Quotes and Ordering

Xing Liu et al.
Journal of virology, 93(17) (2019-06-14)
The Us11 protein encoded by herpes simplex virus 1 (HSV-1) functions to impair autophagy; however, the molecular mechanisms of this inhibition remain to be fully established. Here, we report that the Us11 protein targets tripartite motif protein 23 (TRIM23), which
B cell activating factor (BAFF) selects IL-10? B cells over IL-10+ B cells during inflammatory responses
Ma N, et al.
Molecular Immunology, 85, 18-26 (2017)
Complications in Surgery (2006)
A V Tinker et al.
Gynecologic oncology, 130(2), 269-274 (2013-05-16)
HPV infection has been associated with deregulation of the PI3K-Akt-mTOR pathway in invasive cervical carcinomas. This 2-stage phase II study assessed the activity of the mTOR inhibitor, temsirolimus, in patients with measurable metastatic and/or locally advanced, recurrent carcinoma of the
Carrie L Lucas et al.
Nature immunology, 15(1), 88-97 (2013-10-30)
The p110δ subunit of phosphatidylinositol-3-OH kinase (PI(3)K) is selectively expressed in leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from seven families who were heterozygous for three different germline, gain-of-function mutations in PIK3CD (which encodes p110δ).

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