Rapamycin

Name: Rapamycin
Brand: SIAL
Price: 13788 MXP

VETRANAL^®, analytical standard

Sinónimos:

Sirolimus

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10 MG

MXP 13,788.00

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Fórmula empírica (notación de Hill):

C₅₁H₇₉NO₁₃

Número CAS:

53123-88-9

Peso molecular:

914.17

NACRES:

NA.24

PubChem Substance ID:

329755624

UNSPSC Code:

41116107

MDL number:

MFCD00867594

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Nombre del producto

Rapamycin, VETRANAL^®, analytical standard

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

grade

analytical standard

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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Este artículo	553210	R8781	R0395
Supelco 37094 Rapamycin	Sigma-Aldrich 553210 Rapamycin	Sigma-Aldrich R8781 Rapamycin	Sigma-Aldrich R0395 Rapamycin from Streptomyces hygroscopicus
grade analytical standard	grade -	grade -	grade -
format neat	format -	format -	format -
product line VETRANAL^®	product line -	product line -	product line -
shelf life limited shelf life, expiry date on the label	shelf life -	shelf life -	shelf life -
technique(s) HPLC: suitable	technique(s) -	technique(s) -	technique(s) -
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) -	application(s) -	application(s) -

Application

The analytical standard can be used as follows:

Electrochemical determination of rapamycin using boron-doped diamond electrode and differential pulse voltammetry (DPV) in human urine, serum, and blood samples
Simultaneous determination of six immunosuppressants from whole blood samples by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technique combined with modified QuEChERS method

General description

Rapamycin belongs to the macrolide class of antibiotics obtained from the bacterium Streptomyces hygroscopicus. It was first used as an anti-fungal agent but later also found use as an immunosuppressant and potential anti-cancer drug. It acts by preventing the activity of serine/threonine kinase and subsequently blocking the cytokine-driven T cell proliferation.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS08

signalword

Warning

hcodes

H351,H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

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Certificados de análisis (COA)

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Complications in Surgery (2006)

B cell activating factor (BAFF) selects IL-10? B cells over IL-10+ B cells during inflammatory responses

Ma N, et al.

Molecular Immunology, 85, 18-26 (2017)

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.

Xing Liu et al.

Journal of virology, 93(17) (2019-06-14)

The Us11 protein encoded by herpes simplex virus 1 (HSV-1) functions to impair autophagy; however, the molecular mechanisms of this inhibition remain to be fully established. Here, we report that the Us11 protein targets tripartite motif protein 23 (TRIM23), which

Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199).

A V Tinker et al.

Gynecologic oncology, 130(2), 269-274 (2013-05-16)

HPV infection has been associated with deregulation of the PI3K-Akt-mTOR pathway in invasive cervical carcinomas. This 2-stage phase II study assessed the activity of the mTOR inhibitor, temsirolimus, in patients with measurable metastatic and/or locally advanced, recurrent carcinoma of the

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Carrie L Lucas et al.

Nature immunology, 15(1), 88-97 (2013-10-30)

The p110δ subunit of phosphatidylinositol-3-OH kinase (PI(3)K) is selectively expressed in leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from seven families who were heterozygous for three different germline, gain-of-function mutations in PIK3CD (which encodes p110δ).

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Questions

1–3 of 3 Questions

Anonymous

6 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  6 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

11 months ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  11 months ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
a year ago

How does one take this product? Ingestion or injection?

1 answer
1. Technical Support
  
  a year ago
  
  This product is intended for use as an analytical standard and may not be used for therapeutic or diagnostic purposes for humans or animals.
  
  Helpful?

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