38332

Supelco

Scopoletin

analytical standard

Sinónimos:
Chrysatropic acid, Buxuletin, Escopoletin, 6-Methoxyumbelliferone, 6-Methylesculetin, Esculetin-6-methyl ether, 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one, Gelseminic acid, Murrayetin, 7-Hydroxy-6-methoxycoumarin
Empirical Formula (Hill Notation):
C10H8O4
Número de CAS:
Peso molecular:
192.17
Beilstein/REAXYS Number:
156296
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

assay

≥97.0% (HPLC)

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

203-205 °C (lit.)

Featured Industry

Food and Beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc2C=CC(=O)Oc2cc1O

InChI

1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3

InChI key

RODXRVNMMDRFIK-UHFFFAOYSA-N

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General description

Scopoletin is a coumarin compound and pharmacologically active chemical that is found in various plant species.

Application

Scopoletin may be used as a reference standard for the determination of scopoletin in:
  • Roots, stems, branches, and seeds as well as leaves of Chimonanthus nitens Oliv. by ultra-high performance liquid chromatography/tandem quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS) equipped with modified mass deflect filter or diagnostic product ions/neutral loss filter.
  • Canscora decussate (South Indian Shankhpushpi) extracts by high performance thin layer chromatography (HPTLC).
  • Morinda tinctoria Roxb. leaf by HPTLC in conjunction with HPLC and gas chromatography with MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Scopoletin significantly increases activity of lipoprotein lipase in adipocytes by promoting transcription of the LPL gene. It also partially reverses inhibition of LPL by TNF-α.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Comprehensive profiling and characterization of coumarins from roots, stems, leaves, branches, and seeds of Chimonanthus nitens Oliv. using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with modified mass defect filter.
Tan T, et al.
Journal of Pharmaceutical and Biomedical Analysis, 141(2-3), 140-148 (2017)
Structural characterization and discrimination of Chimonanthus nitens Oliv. leaf from different geographical origins based on multiple chromatographic analysis combined with chemometric methods.
Huang WP, et al.
Journal of Pharmaceutical and Biomedical Analysis, 154(2-3), 236-244 (2018)
HPTLC Finger print analysis and Phytochemical Investigation of Morinda tinctoria Roxb. Leaf extracts by HPLC and GS MS.
Arunachalam KD, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 7(2), 360-366 (2015)
Xiujuan Yao et al.
International immunopharmacology, 14(4), 454-462 (2012-08-24)
The present study determined the anti-inflammatory activity of scopoletin in gout air pouch model and revealed the underlying mechanisms by in vitro assays. Monosodium urate (MSU) crystal-induced inflammation in mouse air pouch model, an experimental model for acute gout, was...
Shakti Deep Pachauri et al.
Journal of ethnopharmacology, 139(1), 34-41 (2011-11-24)
Noni (Morinda citrifolia L.) is widely used for different illnesses including CNS disorders. Recently Noni has been reported to prevent amyloid beta induced memory impairment in mice. However, the influence of Noni on cholinergic system has not been explored so...
Protocolos
Effective analysis of passion flower by HPTLC fingerprinting, in conjunction with a comprehensive range of related reference materials, enables fast and efficient identification of this plant material.
Más información

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