410225

Glycine

ACS reagent, ≥98.5%

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein: 635782
• Número de EC: 200-272-2
• Número MDL: MFCD00008131
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24865701
• NACRES: NA.21

Properties

• grado: ACS reagent
• Nivel de calidad: 200
• ensayo: ≥98.5%
• formulario: crystals; powder or granules
• impurezas: H₂SO₄, passes test (darkened); Hydrolyzable subsances, passes test
• residuo de ign.: ≤0.1%
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• trazas de anión: chloride (Cl^-): ≤0.005%; sulfate (SO₄^2-): ≤0.005%
• trazas de catión: NH₄⁺: ≤0.005%; heavy metals: ≤0.002% (by ICP)
• application(s): peptide synthesis
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Description

Aplicación

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Acciones bioquímicas o fisiológicas

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)