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46429

Supelco

Methimazole

VETRANAL®, analytical standard

Sinónimos:
1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole
Empirical Formula (Hill Notation):
C4H6N2S
Número de CAS:
Peso molecular:
114.17
Beilstein:
108646
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

144-147 °C (lit.)

Featured Industry

Cleaning Products
Clinical
Cosmetics
Food and Beverages
Forensics and Toxicology
Personal Care
Pharmaceutical (small molecule)

format

neat

SMILES string

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChI key

PMRYVIKBURPHAH-UHFFFAOYSA-N

Gene Information

human ... TPO(7173)

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General description

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Methimazole may be used as a reference standard for the determination of the analyte in fish homogenates using mixed mode solid-phase extraction technique with reversed-phase high-performance liquid chromatography method with ultraviolet detection (MMSPE-RP-HPLC-UV).

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Mal-Soon Shin et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(3), 214-223 (2013-01-19)
Thyroid hormones play a crucial role in new neuron production and maturation during brain development. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise...
Yi Wang et al.
Toxicology and applied pharmacology, 271(2), 257-265 (2013-05-28)
Neurotoxicity of iodine deficiency-induced hypothyroidism during developmental period results in serious impairments of brain function, such as learning and memory. These impairments are largely irreversible, and the underlying mechanisms remain unclear. In addition to hypothyroidism, iodine deficiency may cause hypothyroxinemia...
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient...
F S Boretti et al.
Journal of veterinary internal medicine, 27(2), 377-381 (2013-02-13)
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole application. Such information would be valuable for therapeutic monitoring. To assess variation in serum...

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