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73594

Supelco

Ammonium acetate

suitable for mass spectrometry (MS), LiChropur, eluent additive for LC-MS

Fórmula lineal:
CH3CO2NH4
Número de CAS:
Peso molecular:
77.08
Beilstein:
4186741
EC Number:
MDL number:
eCl@ss:
39021908
PubChem Substance ID:
NACRES:
NB.21

Quality Level

grade

eluent additive for LC-MS

assay

≥99.0% (calc. on dry substance, T)

form

solid

quality

LiChropur

application(s)

HPLC: suitable
LC/MS: suitable
mass spectrometry (MS): suitable

impurities

insoluble matter, passes filter test
≤1% water

ign. residue

≤0.01% (as SO4)

pH

6.2-7.5 (25 °C, 1 M in H2O)

mp

110-112 °C (dec.) (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤5 mg/kg
nitrate (NO3-): ≤10 mg/kg
sulfate (SO42-): ≤10 mg/kg

cation traces

Al: ≤1 mg/kg
As: ≤0.1 mg/kg
Ba: ≤1 mg/kg
Bi: ≤1 mg/kg
Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤5 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Mo: ≤1 mg/kg
Na: ≤5 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.015
λ: 280 nm Amax: ≤0.010

SMILES string

N.CC(O)=O

suitability

passes test for LC-MS

InChI

1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3

InChI key

USFZMSVCRYTOJT-UHFFFAOYSA-N

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General description

Ammonium acetate exists as a white crystal. It is prepared from acetic acid and ammonia by neutralization to pH 7.0. It is widely used in analytical chemistry, drugs and in textile dyeing.

Application

Ammonium acetate has been used to prepare eluents for UPLC-MS/MS and HPLC-MS/MS to compare the matrix effect of 9 pharmaceutical compounds in aqueous environmental samples. It has also been used as an additive to improve detection of phosphopeptides using MALDI-MS.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

Dale L. Perry
Handbook of Inorganic Compounds, 17-17 (1995)
Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters.
Van De Steene JC, Lambert WE.
Journal of the American Society For Mass Spectrometry, 19(5), 713-718 (2008)
Enhanced detection of phosphopeptides in matrix-assisted laser desorption/ionization mass spectrometry using ammonium salts.
Asara JM, Allison J.
Journal of the American Society For Mass Spectrometry, 10(1), 35-44 (1999)
J M Asara et al.
Journal of the American Society for Mass Spectrometry, 10(1), 35-44 (1999-01-15)
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been used successfully to detect phosphorylation sites in proteins. Applications may be limited by the low response of phosphopeptides compared to nonphosphorylated peptides in MALDI MS. The addition of ammonium salts to...
Jet C Van De Steene et al.
Journal of the American Society for Mass Spectrometry, 19(5), 713-718 (2008-03-18)
When developing an LC-MS/MS-method matrix effects are a major issue. The effect of co-eluting compounds arising from the matrix can result in signal enhancement or suppression. During method development much attention should be paid to diminishing matrix effects as much...

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