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81845

Sigma-Aldrich

Propidium iodide

≥94% (HPLC)

Sinónimos:
3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide
Empirical Formula (Hill Notation):
C27H34I2N4
Número de CAS:
Peso molecular:
668.39
Beilstein:
3843838
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

200

ensayo

≥94% (HPLC)

mp

220-225 °C (dec.) (lit.)

fluorescencia

λex 482 nm; λem 608 nm (pH 7.2)
λex 540 nm; λem 608 nm (bound to DNA)

temp. de almacenamiento

2-8°C

SMILES string

[I-].[I-].CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14

InChI

1S/C27H33N4.2HI/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20;;/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3;2*1H/q+1;;/p-1

InChI key

XJMOSONTPMZWPB-UHFFFAOYSA-M

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Descripción general

Propidium iodide is a fluorescent intercalating agent used for staining. It functions as an apoptosis marker and has linear DNA-binding capacity. Propidium iodide is an effective indicator of tissue injury.
PI is used for selective labelling of dead cells.

Aplicación

in scrape-loading dye transfer assay
Propidium iodide has been used:
  • to stain DNA in cell cycle analysis
  • to stain cells and cell nuclei
  • for the preparation of propidium iodide (PI)stock solution
  • to stain cells for flow cytometry

Envase

25, 100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Muta. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Certificado de origen

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity
Ponsaerts R, et al.
Faseb Journal, 24(11), 4378-4395 (2010)
Differential nuclear staining assay for high-throughput screening to identify cytotoxic compounds
Carolina L, et al.
Current cellular biochemistry, 1(1), 1-1 (2011)
Intravital microscopic methods to evaluate anti-inflammatory effects and signaling mechanisms evoked by hydrogen sulfide
Methods in Enzymology, 555, 93-125 (2015)
Flow cytometry (2008)
High-throughput, non-perturbing quantification of lipid droplets with Digital Holographic Microscopy
Campos V, et al.
Journal of Lipid Research, jlr-D085217 (2018)

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