Todas las fotos(1)

97622

Supelco

2-Mercaptoethanol

for HPLC derivatization, LiChropur, ≥99.0% (GC)

Sinónimos:
β-Mercaptoethanol, BME, Thioethylene glycol, 2-Hydroxyethylmercaptan
Fórmula lineal:
HSCH2CH2OH
Número de CAS:
Peso molecular:
78.13
Beilstein:
773648
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.05

Nivel de calidad

100

grado

for HPLC derivatization

densidad de vapor

2.69 (vs air)

presión de vapor

1 mmHg ( 20 °C)

ensayo

≥99.0% (GC)

formulario

liquid

calidad

LiChropur

lim. expl.

18 %

concentración

14.3 M (pure liquid)

technique(s)

HPLC: suitable

índice de refracción

n20/D 1.500 (lit.)
n20/D 1.500-1.502

bp

157 °C (lit.)

densidad

1.114 g/mL at 25 °C (lit.)

temp. de almacenamiento

2-8°C

SMILES string

OCCS

InChI

1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2

InChI key

DGVVWUTYPXICAM-UHFFFAOYSA-N

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Descripción general

2-Mercaptoethanol is a thiol compound showing growth promoting properties on mouse lymphoma L1210 cells in vitro. It also enhances viability, blast transformation and antibody formation in lymphocyte cultures.

Aplicación

suitable for derivatisation of Amine groups
BME is suitable for reducing protein disulfide bonds prior to polyacrylamide gel electrophoresis and is usually included in a sample buffer for SDS-PAGE at a concentration of 5%. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.

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Información legal

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Código de clase de almacenamiento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Punto de inflamabilidad F

165.2 °F - closed cup

Punto de inflamabilidad C

74 °C - closed cup

Certificado de Análisis

Certificado de origen

Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine
Ishii T, et al.
The Journal of Biological Chemistry, 256(23), 12387-12392 (1981)
Katharina Rothe et al.
Blood, 123(23), 3622-3634 (2014-04-24)
Previous studies demonstrated that imatinib mesylate (IM) induces autophagy in chronic myeloid leukemia (CML) and that this process is critical to cell survival upon therapy. However, it is not known if the autophagic process differs at basal levels between CML
Leon Tribolet et al.
The Journal of infectious diseases, 211(3), 416-425 (2014-08-21)
Na-ASP-2 is an efficacious hookworm vaccine antigen. However, despite elucidation of its crystal structure and studies addressing its immunobiology, the function of Na-ASP-2 has remained elusive. We probed a 9000-protein human proteome microarray with Na-ASP-2 and showed binding to CD79A
Emily Cunningham Williams et al.
Human molecular genetics, 23(11), 2968-2980 (2014-01-15)
The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes in RTT pathogenesis. However, it is not clear whether this is also true for human RTT astrocytes.
Bethany L Macleod et al.
PLoS pathogens, 10(8), e1004303-e1004303 (2014-08-15)
Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell effector function in situ remains poorly understood. Here, we show key differences in the regulation of effector activity between CD4+ and CD8+ T-cells

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