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Merck

B1116000

Biotina

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

D-Biotina, Bios II, Coenzima R, Vitamina H, Vitaminas B7

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20 MG

MXP 3,941.00

MXP 3,941.00

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Fórmula empírica (notación de Hill):
C10H16N2O3S
Número CAS:
58-85-5
Peso molecular:
244.31
Beilstein/REAXYS Number:
86838
MDL number:
MFCD00005541
UNSPSC Code:
41116107
PubChem Substance ID:
329773165
NACRES:
NA.24

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biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

biotin

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

231-233 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

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1 of 4

Este artículo
PHR12331960691827
Biotina European Pharmacopoeia (EP) Reference Standard

B1116000

Biotina

Biotina Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1233

Biotina

Biotina tested according to Ph. Eur.

Sigma-Aldrich

19606

Biotina

Biotina certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

91827

Biotina

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

clinical testing
pharmaceutical (small molecule)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

-

format

neat

form

solid

form

-

form

-

form

-

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

certified reference material, TraceCERT®

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Biotin is a water-soluble vitamin B, which is involved in the synthesis of fatty acids and in gluconeogenesis.[1][2] It is found in plants and animals. Biotin deficiency causes retardation in growth, alopecia and neurological impairment in humans and animals.[3]

Application

Biotin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.[4][5]

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Clase de almacenamiento

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

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Biotin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 16(8), 5631-5632 (2018)
Liquid chromatographic determination of biotin in multivitamin-multimineral tablets.
Ekpe AE and Hazen C
Journal of Pharmaceutical and Biomedical Analysis, 16(8), 1311-1315 (1998)
Agar plate method using Lactobacillus plantarum for biotin determination in serum and urine
FUKUI T, et al.
J. Nutr. Sci. Vitaminol., 40(5), 491-498 (1994)
Factitious Graves disease due to biotin immunoassay interference-a case and review of the literature
Elston MS, et al.
The Journal of clinical endocrinology and metabolism, 101(9), 3251-3255 (2016)
Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
Cyran CC, et al.
Investigative Radiology, 43(5), 298-298 (2008)
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