Merck
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E4884

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

ACS reagent, 99.0-101.0%

Sinónimos:
Edetate disodium salt dihydrate, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, Edathamil, EDTA-Na2, Sequestrene Na2
Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
Número de CAS:
Peso molecular:
372.24
Beilstein:
3900609
Número de EC:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

200

grado

ACS reagent

ensayo

99.0-101.0%

formulario

solid

impurezas

≤0.005% Insoluble matter
≤0.1% Nitrilotriacetic acid ([HOCOCH2]3N)

pH

4.0-6.0 (25 °C, 5%)

mp

248 °C (dec.) (lit.)

solubilidad

H2O: 100 g/L at 20 °C

trazas de catión

Fe: ≤0.01%
heavy metals (as Pb): ≤0.005%

temp. de almacenamiento

room temp

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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Descripción general

EDTA is a chelator of divalent cations. It inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Aplicación

Ethylenediaminetetraacetic acid disodium salt dehydrate has been used as a component:
  • of radioimmunoprecipitation assay buffer (RIPA buffer) for preparation of C2C12 mouse skeletal myoblasts whole cell lysate
  • of lysis buffer and IgG resin wash and equilibration buffer for the purification of human proteasome regulatory particles (RPs)
  • of M-buffer for the isolation of human cardiomyocyte progenitor cells (CMPCs) from fetal heart

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Envase

100, 500 g in poly bottle

Acciones bioquímicas o fisiológicas

Ethylenediaminetetraacetic acid (EDTA) is an anticoagulant, majorly used in preventing clotting of blood. EDTA may trigger aggregation of platelets resulting in pseudothrombocytopenia. EDTA along with tetracycline serves as a root conditioning agent and provides relief in gum infection. EDTA-tetracycline therapy decreases coronary artery calcium levels in atherosclerosis. Calcium disodium EDTA administration is effective in slowing down the progression of chronic kidney disease. It also enhances the antimicrobial functionality of lysozyme and improves shelf life of cheese.

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - STOT RE 2 Inhalation

Órganos de actuación

Respiratory Tract

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

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Certificado de origen

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Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms
Smit NW, et al.
Frontiers in Physiology, 8, 797-797 (2017)
Conformational landscape of the p28-bound human proteasome regulatory particle
Lu Y, et al.
Molecular Cell, 67(2), 322-333 (2017)
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts
Sin J, et al.
Autophagy, 12(2), 369-380 (2016)
Comparison of the efficacy of ethylenediaminetetraacetic acid and tetracycline hydrochloride as root conditioning agents: An in vitro study
Nanda T, et al.
Journal of the International Clinical Dental Research Organization, 4(1), 2-2 (2012)
Serena Duchi et al.
Materials (Basel, Switzerland), 12(4) (2019-02-23)
Cartilage defects and diseases remain major clinical issues in orthopaedics. Biomanufacturing is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. However, several limitations of in vitro and experimental animal models pose serious

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