Merck
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I3377

Supelco

Isoniazid

analytical standard, ≥99% (TLC)

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Sinónimos:
INH, 4-Pyridinecarboxylic acid hydrazide, Isonicotinic acid hydrazide, Isonicotinic hydrazide
Empirical Formula (Hill Notation):
C6H7N3O
Número de CAS:
54-85-3
Peso molecular:
137.14
Beilstein:
119374
Número de EC:
200-214-6
Número MDL:
MFCD00006426
ID de la sustancia en PubChem:
329815370
NACRES:
NA.24

Nivel de calidad

100

grado

analytical standard

ensayo

≥99% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

171-173 °C (lit.)

fluorescencia

λex 360 nm; λem 450 nm (thiol adduct)

espectro de actividad antibiótica

mycobacteria

application(s)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

SMILES string

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChI key

QRXWMOHMRWLFEY-UHFFFAOYSA-N

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Categorías relacionadas

Descripción general

Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.
Chemical structure: pyridine

Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Envase

5, 50, 250 g in poly bottle

Acciones bioquímicas o fisiológicas

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302 - H315

Clasificaciones de peligro

Acute Tox. 4 Oral - Skin Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Introduzca el número de lote para buscar un certificado de análisis (COA).

Certificado de origen

Introduzca el número de lote para buscar un Certificado de origen (COO).

Más documentos

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Quotes and Ordering

Bulk Quote-Order Product
Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class
A fresh look at the mechanism of isoniazid-induced hepatotoxicity.
I G Metushi et al.
Clinical pharmacology and therapeutics, 89(6), 911-914 (2011-03-18)
Chang Dong Han et al.
Clinical orthopaedics and related research, 471(7), 2400-2406 (2013-03-19)
Antibiotic-loaded bone cement (ALBC) has been used in serious cases of musculoskeletal tuberculosis, but the type and amount of antibiotic that should be used in ALBC have not been determined. We therefore determined the (1) elution characteristics and (2) antimycobacterial
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