Merck
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PHR1045

Supelco

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
DEG, 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol
Linear Formula:
(HOCH2CH2)2O
CAS Number:
Molecular Weight:
106.12
Beilstein:
969209
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to Ph. Eur. Y0000217
traceable to USP 1193265

densidad de vapor

2.14 (vs air)

presión de vapor

0.01 mmHg ( 20 °C)

CofA

current certificate can be downloaded

temp. de autoignición

442 °F

lim. expl.

2-12.3 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.447 (lit.)

bp

245 °C (lit.)

mp

−10 °C (lit.)

densidad

1.118 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

SMILES string

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Aplicación

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

280.4 °F - closed cup

Punto de inflamabilidad C

138 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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