PHR1098

N-Acetyl-L-cysteine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): LNAC, NAC
• Linear Formula: HSCH₂CH(NHCOCH₃)CO₂H
• CAS Number: 616-91-1
• Molecular Weight: 163.19
• Beilstein: 1724426
• Número de EC: 210-498-3
• Número MDL: MFCD00004880
• ID de la sustancia en PubChem: 329823120
• NACRES: NA.24

Properties

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 907; traceable to Ph. Eur. A0150000; traceable to USP 1009005
• CofA: current certificate can be downloaded
• condiciones de almacenamiento: protect from light
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 106-108 °C (lit.)
• application(s): pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-8°C
• SMILES string: CC(=O)N[C@@H](CS)C(O)=O
• InChI: 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
• InChI key: PWKSKIMOESPYIA-BYPYZUCNSA-N

Description

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine.[1] It finds use in clinical applications as a mucolytic agent typically administered by inhalation.[2]

Aplicación

N-Acetyl-L-cysteine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography-mass spectrometry (LC-MS)[3] and spectrophotometric[1] techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0297in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 13 - Non Combustible Solids
• WGK: WGK 2
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable