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(±)-Verapamil hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
Fórmula lineal:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Número de CAS:
Peso molecular:
Número de EC:
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad



certified reference material
pharmaceutical secondary standard


traceable to Ph. Eur. V0100000
traceable to USP 1711202


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


142 °C (dec.) (lit.)


pharmaceutical (small molecule)



temp. de almacenamiento


SMILES string




InChI key


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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Verapamil hydrochloride is a calcium channel blocker used commonly for the management of angina, supra-ventricular tachyarrhythmia, hypertension, migraine and atrial tachyarrhythmias.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Verapamil hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in drug raw material and pharmaceutical formulations by high performance liquid chromatography and spectrophotometric method, respectively.

Acciones bioquímicas o fisiológicas

α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA5980 in the slot below. This is an example certificate only and may not be the lot that you receive.


Skull and crossbonesEnvironment

Palabra de señalización


Frases de peligro

Clasificaciones de peligro

Acute Tox. 3 Oral - Aquatic Chronic 2

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Introduzca el número de lote para buscar un certificado de análisis (COA).

Certificado de origen

Introduzca el número de lote para buscar un Certificado de origen (COO).

Más documentos

Quotes and Ordering

High-performance liquid chromatographic method for the assay of verapamil hydrochloride and related compounds in raw material
Lacroix PM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 9(10-12), 817-822 (1991)
Spectrophotometric method for the determination of verapamil hydrochloride in pharmaceutical formulations using N-bromosuccinimide as oxidant
Rahman N et al.
Il Farmaco (Societa Chimica Italiana : 1989), 59(7), 529-536 (2004)
Overdose of sustained-release verapamil
Barrow PM, et al.
British journal of anaesthesia, 72(3), 361-365 (1994)
Irena Roci et al.
Cell cycle (Georgetown, Tex.), 19(20), 2676-2684 (2020-10-06)
Proliferating cells must synthesize a wide variety of macromolecules while progressing through the cell cycle, but the coordination between cell cycle progression and cellular metabolism is still poorly understood. To identify metabolic processes that oscillate over the cell cycle, we
Shashank Gupta et al.
American journal of respiratory and critical care medicine, 188(5), 600-607 (2013-06-29)
A major priority in tuberculosis (TB) is to reduce effective treatment times and emergence of resistance. Recent studies in macrophages and zebrafish show that inhibition of mycobacterial efflux pumps with verapamil reduces the bacterial drug tolerance and may enhance drug


LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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