PHR1379

Atropine Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate
• Linear Formula: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• CAS Number: 5908-99-6
• Molecular Weight: 694.83
• Beilstein: 6109275
• Número de EC: 200-235-0
• Número MDL: MFCD00074815
• ID de la sustancia en PubChem: 329823356
• NACRES: NA.24

Properties

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 23; traceable to Ph. Eur. A1400000; traceable to USP 1045009
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 189-192 °C (A) (lit.)
• application(s): pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-8°C
• SMILES string: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChI key: JPKKQJKQTPNWTR-CHYDPLAESA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

Description

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Atropine Sulfate is an alkaloid extracted from belladonna herb. It is a cholinergic drug, administered as an anti-arrhythmic medicine.[1]

Aplicación

Atropine Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrophoresis[2] and chromatography techniques.[3][4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC4087 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300 + H330
• Consejos de prudencia: P301 + P310 + P330 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable