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Arginine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

L-Arginine monohydrochloride, (S)-(+)-Arginine hydrochloride, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
Número de CAS:
Peso molecular:
Número de EC:
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad



certified reference material
pharmaceutical secondary standard


current certificate can be downloaded


pkg of 1 g


HPLC: suitable
gas chromatography (GC): suitable


236-230 °C (lit.)


pharmaceutical (small molecule)



trazabilidad farmacopeica

traceable to BP 694
traceable to PhEur A1271000
traceable to USP 1042601

temp. de almacenamiento


SMILES string




InChI key


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Descripción general

Arginine Hydrochloride is a salt of arginine, which is a semi-essential amino acid. This dibasic amino acid acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Arginine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, dietary supplements and capsules by chromatography.

Acciones bioquímicas o fisiológicas

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA3002 in the slot below. This is an example certificate only and may not be the lot that you receive.

Código de clase de almacenamiento

13 - Non Combustible Solids



Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Arginine Hydrochloride
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 44(5), 366-366 (2018)
Quantification of arginine in dietary supplement tablets and capsules by silica gel high-performance thin-layer chromatography with visible mode densitometry
Hess B and Sherma J
Acta Chromatographica , 60-69 (2004)
Nivaldo Ribeiro Villela et al.
Journal of translational medicine, 12, 232-232 (2014-08-26)
Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. This paper investigates the role of the nitric oxide
Jenna Gallie et al.
PLoS biology, 13(3), e1002109-e1002109 (2015-03-13)
Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to
X Zheng et al.
Journal of dental research, 94(2), 344-353 (2014-12-06)
Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely used anticaries agent, which promotes tooth hard-tissue remineralization and suppresses bacterial activities. Recent clinical trials have

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