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tert-Butyl Methyl Ether

Pharmaceutical Secondary Standard; Certified Reference Material

MTBE, tert-Butyl methyl ether, Methyl tert-butyl ether
Fórmula lineal:
Número de CAS:
Peso molecular:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


certified reference material
pharmaceutical secondary standard

vapor density

3.1 (vs air)


current certificate can be downloaded

autoignition temp.

705 °F

expl. lim.

15.1 %


ampule of 3x1.2 mL


HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.369 (lit.)


55-56 °C (lit.)


0.74 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to USP 1083303

SMILES string




InChI key


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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. tert-Butyl methyl ether (MTBE) is a gasoline additive. It is a commonly used organic solvent that can be synthesized by acid catalyzed reaction between methanol and isobutene. It is also an effective alternative to lead containing additives for enhancing the octane rating of gasoline.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC2091 in the slot below. This is an example certificate only and may not be the lot that you receive.


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Hazard Classifications

Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK Germany


Flash Point F

-27.4 °F - closed cup

Flash Point C

-33.0 °C - closed cup

Certificado de Análisis

Certificado de origen

Ceinwen A Schreiner et al.
Regulatory toxicology and pharmacology : RTP, 70(2 Suppl), S29-S34 (2014-05-24)
Micronucleus and sister chromatid exchange (SCE) tests were performed for vapor condensate of baseline gasoline (BGVC), or gasoline with oxygenates, methyl tert-butyl ether (G/MTBE), ethyl tert butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), t-butyl alcohol (TBA), or...
Yi-Hsueh Chuang et al.
Journal of hazardous materials, 283, 218-226 (2014-10-04)
During the chloramination of natural waters, both chloramines and dissolved organic nitrogen (DON) can serve as nitrogen sources for the formation of trichloronitromethane (TCNM) and dichloroacetonitrile (DCAN). The present study investigated the formation kinetics and precursor characteristics of TCNM and...
Hiroki Toshima et al.
Journal of analytical toxicology, 39(2), 133-136 (2014-12-30)
During a cross-validation practice of urinary analysis of pyrethroid insecticide metabolite (3-phenoxybenzoic acid, 3-PBA) by two laboratories (Lab A and Lab B), difference in 3-PBA concentration was noticed. The analytical methods used in the exercise were enzymatic deconjugation (glucuronidase/sulfatase) followed...
Jiaqi Liu et al.
Water research, 65, 64-72 (2014-08-05)
Using seawater for toilet flushing effectively reduces the consumption of precious freshwater resources, yet it introduces bromide and iodide ions into a wastewater treatment system, which may form bromo- and iodo-disinfection byproducts (DBPs) during chlorination of the wastewater effluent. Most...
Ruth B Lathi et al.
Fertility and sterility, 102(1), 123-128 (2014-04-22)
To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk. Retrospective cohort of prospectively collected serum samples. Academic fertility center. Women presenting for early pregnancy monitoring with...


GC Analysis of Class 3 Residual Solvents on OVI-G43

Butyl methyl ether; Acetic acid; 2-Butanone; Ethyl acetate; Tetrahydrofuran; 1-Butanol; Isopropyl acetate; Heptane; Propyl acetate; 3-Methylbutanol; 4-Methyl-2-pentanone; Isobutyl acetate; Butyl acetate; Dimethyl sulfoxide; Anisole; Cumene


GC Analysis of Class 3 Residual Solvents on SUPELCOWAX® 10

Protocol for GC Analysis of Class 3 Residual Solvents on SUPELCOWAX® 10

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