S6501

Streptomycin sulfate salt

powder

• Fórmula lineal: C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄
• Número de CAS: 3810-74-0
• Peso molecular: 728.69
• Beilstein: 3894995
• Número de EC: 223-286-0
• Número MDL: MFCD00037023
• ID de la sustancia en PubChem: 24899705
• NACRES: NA.76

Propiedades

• Nivel de calidad: 200
• origen biológico: Streptomyces griseus
• formulario: powder
• potencia: ≥720 I.U. per mg
• mol peso: calculated mol wt 1457.38 ((C₂₁H₃₉N₇O₁₂)₂ ⋅3H₂O₄S)
• condiciones de almacenamiento: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• color: white to off-white
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Modo de acción: protein synthesis | interferes
• temp. de almacenamiento: 2-8°C
• SMILES string: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
• InChI key: QTENRWWVYAAPBI-YZTFXSNBSA-N

Descripción

Descripción general

Chemical structure: aminoglycoside

Envase

5, 25, 50, 100 g in poly bottle

1 kg in poly bottle

Aplicación

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Acciones bioquímicas o fisiológicas

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Precaución

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Nota de preparación

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Información de seguridad

• pictogramas: GHS07,GHS08
• Palabra de señalización: Warning
• Frases de peligro: H302 - H361fd
• Consejos de prudencia: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves