Merck
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30970

Sigma-Aldrich

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

Sinónimos:
3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO4
Número de CAS:
Peso molecular:
414.55
Beilstein:
3581950
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.21

origen biológico

ox bile

Nivel de calidad

descripción

anionic

Línea del producto

BioXtra

Análisis

≥98.0% (dry matter, NT)

formulario

powder

actividad óptica

[α]20/D +44±2°, c = 2% in H2O

mol peso

micellar avg mol wt 1200-5000

número de agregación

3-12

technique(s)

DNA purification: suitable
RNA purification: suitable
electrophoresis: suitable

impurezas

≤1% cholic acid (HPLC)
≤6% water

CMC

2-6 mM (20-25°C)

solubilidad

water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow

trazas de catión

Ca: ≤500 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
Mg: ≤10 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg
Zn: ≤5 mg/kg

HLB

16

grupo funcional

carboxylic acid

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

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Este artículo
SRE0046D6750S1827
Sodium deoxycholate BioXtra, ≥98.0% (dry matter, NT)

Sigma-Aldrich

30970

Sodium deoxycholate

Sodium deoxycholate Suitable for manufacturing of diagnostic kits and reagents

Sigma-Aldrich

SRE0046

Sodium deoxycholate

Sodium deoxycholate ≥97% (titration)

Sigma-Aldrich

D6750

Sodium deoxycholate

Sodium deoxycholate

SAFC

S1827

Sodium deoxycholate

description

anionic

description

-

description

anionic

description

-

product line

BioXtra

product line

-

product line

-

product line

-

assay

≥98.0% (dry matter, NT)

assay

≥98% (HPLC)

assay

≥97% (titration)

assay

≥98% (HPLC)

form

powder

form

-

form

powder

form

powder

mol wt

micellar avg mol wt 1200-5000

mol wt

micellar avg mol wt 1200-5000

mol wt

micellar avg mol wt 1200-5000

mol wt

micellar avg mol wt 1200-5000

Descripción general

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Aplicación

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Acciones bioquímicas o fisiológicas

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Características y beneficios

  • Suitable for Cell Biology and Biochemical Research
  • Can be used in Electrophoresis, DNA and RNA purification
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
  • High purity product for research applications

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Xylitol ≥99%

Sigma-Aldrich

X3375

Xylitol

Selective dissociation of histones from chromatin by sodium deoxycholate.
J E Smart et al.
Journal of molecular biology, 58(3), 651-659 (1971-06-28)
G Ramadori et al.
The Journal of experimental medicine, 162(3), 930-942 (1985-09-01)
During the acute phase response to tissue injury or inflammation, the concentration of several plasma proteins change. Previous work (29-34) suggested a role for interleukin 1 (IL-1) in the acute phase response. The availability of recombinant-generated mouse IL-1 prompted a
Y L Lo et al.
Biochemical pharmacology, 59(6), 665-672 (2000-02-25)
The effects of sodium deoxycholate (Deo-Na), a bile salt, and sodium caprate (Cap-Na), a fatty acid, on the transport of epirubicin were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat
A Helenius et al.
Biochimica et biophysica acta, 436(2), 319-334 (1976-06-17)
The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration and causes lysis of the viral membrane at 0.9 +/-
Gang Chen et al.
Autophagy, 8(11), 1577-1589 (2012-08-10)
Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. The mechanisms underlying ethanol-induced neurodegeneration are complex. Ethanol exposure produces reactive oxygen species (ROS) which cause oxidative stress in the brain. We hypothesized that

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