51878

Sigma-Aldrich

α-Ketosuberic acid

≥97.0% (HPLC)

Sinónimos:
2-Ketosuberic acid, 2-Oxooctanedioic acid
Empirical Formula (Hill Notation):
C8H12O5
Número de CAS:
Peso molecular:
188.18
Beilstein/REAXYS Number:
1778635
MDL number:
NACRES:
NA.25

Quality Level

assay

≥97.0% (HPLC)

storage temp.

2-8°C

InChI

1S/C8H12O5/c9-6(8(12)13)4-2-1-3-5-7(10)11/h1-5H2,(H,10,11)(H,12,13)

InChI key

HAGOOZVJLSSXGZ-UHFFFAOYSA-N

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

David E Graham
Methods in enzymology, 494, 301-326 (2011-03-16)
Coenzyme M (CoM) and coenzyme B (CoB) are essential for methane production by the euryarchaea that employ this specialized anaerobic metabolism. Two pathways are known to produce CoM, 2-mercaptoethanesulfonate, and both converge on the 2-oxoacid sulfopyruvate. These cells have recruited...
Randy M Drevland et al.
The Journal of biological chemistry, 283(43), 28888-28896 (2008-09-04)
Homoaconitase enzymes catalyze hydrolyase reactions in the alpha-aminoadipate pathway for lysine biosynthesis or the 2-oxosuberate pathway for methanogenic coenzyme B biosynthesis. Despite the homology of this iron-sulfur protein to aconitase, previously studied homoaconitases catalyze only the hydration of cis-homoaconitate to...
Yuchen Liu et al.
Environmental microbiology, 14(10), 2632-2644 (2012-05-26)
Studies on sulfur metabolism in archaea have revealed many novel enzymes and pathways and have advanced our understanding on metabolic processes, not only of the archaea, but of biology in general. A variety of dissimilatory sulfur metabolisms, i.e. reactions used...
R H White
Biochemistry, 28(24), 9417-9423 (1989-11-28)
The biosynthetic steps involved in the conversion of alpha-ketosuberate to 7-mercaptoheptanoic acid were studied in cell-free extracts of methanogenic bacteria. The pathway was established by measuring the incorporation of stable isotopically labeled precursors into the S-methyl ether methyl ester derivative...
Jeyaraman Jeyakanthan et al.
Biochemistry, 49(12), 2687-2696 (2010-02-23)
The aconitase family of hydro-lyase enzymes includes three classes of proteins that catalyze the isomerization of alpha-hydroxy acids to beta-hydroxy acids. Besides aconitase, isopropylmalate isomerase (IPMI) proteins specifically catalyze the isomerization of alpha,beta-dicarboxylates with hydrophobic gamma-chain groups, and homoaconitase (HACN)...

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