A7106

Azelnidipine

≥98% (HPLC), powder

• Sinónimos: 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester, CS-905, RS-9054
• Empirical Formula (Hill Notation): C₃₃H₃₄N₄O₆
• Número de CAS: 123524-52-7
• Peso molecular: 582.65
• MDL number: MFCD00865803
• PubChem Substance ID: 329770914

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• originator: Daiichi-Sankyo
• storage temp.: room temp
• SMILES string: CC(C)OC(=O)C1=C(C)NC(N)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC3CN(C3)C(c4ccccc4)c5ccccc5
• InChI: 1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
• InChI key: ZKFQEACEUNWPMT-UHFFFAOYSA-N

Descripción

Application

Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302 - H318
• pcodes: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves
• RIDADR: NONH for all modes of transport
• WGK Germany: WGK 3
• Flash Point F: Not applicable
• Flash Point C: Not applicable