A7106

Azelnidipine

≥98% (HPLC), powder

• Synonym(s): 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester, CS-905, RS-9054
• Empirical Formula (Hill Notation): C₃₃H₃₄N₄O₆
• CAS Number: 123524-52-7
• Molecular Weight: 582.65
• Número MDL: MFCD00865803
• ID de la sustancia en PubChem: 329770914

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• solubilidad: DMSO: >10 mg/mL
• emisor: Daiichi-Sankyo
• temp. de almacenamiento: room temp
• SMILES string: CC(C)OC(=O)C1=C(C)NC(N)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC3CN(C3)C(c4ccccc4)c5ccccc5
• InChI: 1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
• InChI key: ZKFQEACEUNWPMT-UHFFFAOYSA-N

Description

Aplicación

Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.

Envase

10, 50 mg in glass bottle

Acciones bioquímicas o fisiológicas

Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.

Características y beneficios

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictogramas: GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302 - H318
• Consejos de prudencia: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Dam. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves