Merck
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B2682

Sigma-Aldrich

Boc-Asp(OMe)-fluoromethyl ketone

≥90% (TLC), solid

Synonym(s):
Boc-D-FMK
Empirical Formula (Hill Notation):
C11H18NO5F
CAS Number:
Molecular Weight:
263.26
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥90% (TLC)

formulario

solid

solubilidad

DMF: soluble

temp. de almacenamiento

−20°C

SMILES string

COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF

InChI

1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1

Inchi Key

MXOOUCRHWJYCAL-ZETCQYMHSA-N

Aplicación

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells [1], as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice [2], as a protease inhibitor to study its effects on cell death in parasites [3].

Envase

3 mg in glass bottle

Acciones bioquímicas o fisiológicas

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli.[4] Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.[5]

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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