Merck
All Photos(1)

B7431

Sigma-Aldrich

Bryostatin 1

≥99%, solid

Synonym(s):
NSC 339555
Empirical Formula (Hill Notation):
C47H68O17
CAS Number:
Molecular Weight:
905.03
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥99%

formulario

solid

color

white

solubilidad

DMSO: soluble
ethanol: soluble

temp. de almacenamiento

−20°C

SMILES string

[H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C

InChI

1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChI key

MJQUEDHRCUIRLF-TVIXENOKSA-N

Aplicación

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice.[1] It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.[2]

Envase

10 μg in ampule

Acciones bioquímicas o fisiológicas

Bryostatin 1 (Bry1) is a macrocyclic lactone.[3] This synaptogenic compound[4] is obtained from the marine bryozoan Bugula neritina.[1] Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders.[3] It possesses antidepressant activity, when administered intracebroventricularly.[4] Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.[1]
Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.

Otras notas

Binds to glass and plastic in aqueous solutions

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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