C2759

Carbonyl cyanide 3-chlorophenylhydrazone

≥97% (TLC), powder

• Synonym(s): m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
• Empirical Formula (Hill Notation): C₉H₅ClN₄
• CAS Number: 555-60-2
• Molecular Weight: 204.62
• Beilstein: 1842102
• Número de EC: 209-103-7
• Número MDL: MFCD00001848
• ID de la sustancia en PubChem: 24892523
• NACRES: NA.77

Properties

• Nivel de calidad: 200
• ensayo: ≥97% (TLC)
• formulario: powder
• color: yellow to orange
• solubilidad: DMSO: 100 mM
• temp. de almacenamiento: −20°C
• SMILES string: Clc1cccc(N\N=C(\C#N)C#N)c1
• InChI: 1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
• InChI key: UGTJLJZQQFGTJD-UHFFFAOYSA-N

Description

Aplicación

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:

• in the inhibition of efflux pump in clinical Pseudomonas aeruginosa
• to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells
• to prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans

Envase

100 mg in glass insert

1 g in glass bottle

250 mg in glass bottle

Acciones bioquímicas o fisiológicas

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells. CCCP suppresses the expression of few electron transport chain (ETC) proteins. Protonophore (H⁺ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl^- uptake and Cl^-/Cl^- exchange activities in brush-border membrane vesicles.

Safety Information

• pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301 + H311 + H331 - H315 - H319 - H335
• Consejos de prudencia: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges