C8755

Sigma-Aldrich

L-Cystine

≥98% (TLC), crystalline

Sinónimos:
(R,R)-3,3′-Dithiobis(2-aminopropionicacid)
Fórmula lineal:
[-SCH2CH(NH2)CO2H]2
Número de CAS:
Peso molecular:
240.30
Beilstein/REAXYS Number:
1728094
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

biological source

human hair

assay

≥98% (TLC)

form

crystalline

application(s)

cell analysis: suitable
peptide synthesis: suitable

color

white to off-white

mp

>240 °C (dec.) (lit.)

solubility

1 M HCl: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

InChI key

LEVWYRKDKASIDU-IMJSIDKUSA-N

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Application

L-Cystine has been used in in vitro cystine solubility assay to identify potential drugs that influence cystine solubility. It is also used as a supplement of phosphate-buffered saline to slice and wash periprosthetic tissues.

Packaging

1 kg in poly bottle
100, 500 g in poly bottle

Biochem/physiol Actions

Cysteine is the source of disulfide linkages in proteins and has a role in sulfur transport. It undergoes rapid oxidation to form cystine at physiological pH. L-cystine is crucial for oxygen production and low density lipoprotein modification by arterial smooth muscle cells. It also has a role in the synthesis of glutathione.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases
Maisie Lo
Journal of Cellular Physiology, 215(215) (2008)
Wear particles and ions from cemented and uncemented titanium-based hip prostheses?A histological and chemical analysis of retrieval material
Susann Grosse
Journal of Biomedical Materials Research, 709?717-709?717 (2015)
The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.
Heinecke JW
The Journal of Biological Chemistry, 262(21), 10098-10103 (1987)
Mass Spectrometry-based in vitro Assay to Identify Drugs that Influence Cystine Solubility
Neelanjan Bose
Bio-protocol, 7(14), e2417-e2417 (2017)
Ojore Benedict Valentine Oka et al.
Molecular cell, 50(6), 793-804 (2013-06-19)
ERdj5 is a member of the protein disulfide isomerase family of proteins localized to the endoplasmic reticulum (ER) of mammalian cells. To date, only a limited number of substrates for ERdj5 are known. Here we identify a number of endogenous...

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