D1662

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 35,000-45,000

Fórmula lineal:
(C6H10O5)n
Número de CAS:
EC Number:
MDL number:

Quality Level

biological source

bacterial (Leuconostoc mesenteroides)

form

powder

optical activity

[α]/D 199°

mol wt

average mol wt 35,000-45,000

solubility

H2O: 100 mg/mL, clear, colorless

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Application

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextran 40 may be derivatized for use as a cell permeation reagent.
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

Packaging

10, 50, 100, 500 g in poly bottle

Linkage

Similar to D4133, but from another supplier.

Preparation Note

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

Baris Dogu Yildiz et al.
The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique, 21(2), 83-86 (2014-01-17)
Postoperative management of patients after modified radical mastectomy has evolved over the past decades. In the early postoperative period, wound complication rates were reported to be as high as 60%. Flap necrosis after modified radical mastectomy is a common problem...
Rong Cao et al.
Talanta, 165, 357-363 (2017-02-06)
Paper with immobilized protein can provide a low-cost platform for diagnostics, but evidence is emerging that the instability of protein on paper during shipping and storage severely limits its commercial development. Of these, paper-immobilized antibody, though widely used, is in...
David Latrasse et al.
Genome biology, 18(1), 131-131 (2017-07-08)
Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin...
Carlos Tassa et al.
Accounts of chemical research, 44(10), 842-852 (2011-06-15)
Advances in our understanding of the genetic basis of disease susceptibility coupled with prominent successes for molecular targeted therapies have resulted in an emerging strategy of personalized medicine. This approach envisions risk stratification and therapeutic selection based on an individual's...
Yang Yang et al.
Biochimica et biophysica acta, 1840(1), 288-293 (2013-10-01)
Abnormal adhesion of red blood cells (RBCs) to vascular endothelium is often associated with reduced levels of sialic acids on RBC membranes and with elevated levels of pro-adhesive plasma proteins. However, the synergistic effects of these two factors on the...
Protocolos
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist.
Más información
Contenido relacionado
Learn about C6H10O6 or dextran formation, classes and naming from MilliporeSigma. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.
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