D4628

Diethylstilbestrol

≥99% (HPLC)

• Synonym(s): Stilbestrol, (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES
• Empirical Formula (Hill Notation): C₁₈H₂₀O₂
• CAS Number: 56-53-1
• Molecular Weight: 268.35
• Beilstein: 2056095
• Número de EC: 200-278-5
• Número MDL: MFCD00002373
• ID de la sustancia en PubChem: 24893887
• NACRES: NA.77

Properties

• Nivel de calidad: 200
• ensayo: ≥99% (HPLC)
• formulario: powder
• SMILES string: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
• InChI key: RGLYKWWBQGJZGM-ISLYRVAYSA-N
• Gene Information: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890)

Description

Aplicación

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
• to detect its effect on the proliferation and tyrosinase activity of melanocytes

Acciones bioquímicas o fisiológicas

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

Safety Information

• pictogramas: GHS07,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H315 - H319 - H335 - H350 - H360FD - H410
• Consejos de prudencia: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges