D8893

Dexamethasone

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

• Sinónimos: 9α-Fluoro-16α-methylprednisolone, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
• Número de CAS: 50-02-2
• Peso molecular: 392.46
• Beilstein: 2066651
• Número de EC: 200-003-9
• Número MDL: MFCD00064136
• ID de la sustancia en PubChem: 24894235
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• origen biológico: synthetic (organic)
• esterilidad: γ-irradiated
• línea de producto: BioXtra
• ensayo: ≥80% (HPLC)
• formulario: powder
• potencia: 4-500 ng/mL
• technique(s): cell culture | mammalian: suitable
• mp: 262-264 °C (lit.)
• solubilidad: ethanol: 1 mL/vial, clear
• enviado en: ambient
• temp. de almacenamiento: 2-8°C
• SMILES string: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Gene Information: human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926) ; rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

Descripción

Aplicación

Dexamethasone has been used as a component of osteogenic differentiation medium. It has also been used to study apoptosis, cell signaling pathways and gene expression.

Acciones bioquímicas o fisiológicas

Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins. It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Forma física

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitución

To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Información de seguridad

• pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H360FD
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves