E7781

Erastin

≥98% (HPLC), powder, ferroptosis inducer

• Sinónimos: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
• Fórmula empírica (notación de Hill): C₃₀H₃₁ClN₄O₄
• Número de CAS: 571203-78-6
• Peso molecular: 547.04
• Número MDL: MFCD09837984
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329799073
• NACRES: NA.77

Propiedades

• Nombre del producto: Erastin, ≥98% (HPLC)
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5
• InChI: 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
• Clave InChI: BKQFRNYHFIQEKN-UHFFFAOYSA-N
• Información sobre el gen: human ... hRas(3265) ; mouse ... hRas(15461) ; rat ... hRas(293621)

Descripción

Descripción general

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc^-.[1]

Aplicación

Erastin has been used:

• as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)[2]
• to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells[3]
• to induce ferroptosis of muscle-derived cell lines[4]

Acciones bioquímicas o fisiológicas

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges