Merck

E7781

Sigma-Aldrich

Erastin

≥98% (HPLC)

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Sinónimos:
2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
Empirical Formula (Hill Notation):
C30H31ClN4O4
Número de CAS:
Peso molecular:
547.04
Número MDL:
ID de la sustancia en PubChem:

Análisis

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

−20°C

SMILES string

CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

Gene Information

human ... hRas(3265)
mouse ... hRas(15461)
rat ... hRas(293621)

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Este artículo
SML2794SML2231E9531
Erastin ≥98% (HPLC)

Sigma-Aldrich

E7781

Erastin

Erastin2 ≥98% (HPLC)

Sigma-Aldrich

SML2794

Erastin2

Erasin ≥98% (HPLC)

Sigma-Aldrich

SML2231

Erasin

Ebastine ≥98% (HPLC), solid

Sigma-Aldrich

E9531

Ebastine

form

powder

form

powder

form

powder

form

solid

color

white to beige

color

white to beige

color

white to beige

color

white

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

Gene Information

human ... hRas(3265)
mouse ... hRas(15461)
rat ... hRas(293621)

Gene Information

-

Gene Information

-

Gene Information

-

Descripción general

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.

Aplicación

Erastin has been used:
  • as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
  • to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
  • to induce ferroptosis of muscle-derived cell lines

Acciones bioquímicas o fisiológicas

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


Certificates of Analysis (COA)

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Las referencias de los producto se combinan con los tamaños de envase y las cantidades cuando se muestran en la página web, por ejemplo: T1503-25G. Asegúrese de introducir el número de producto ÚNICAMENTE en el campo del Número de producto (ejemplo: T1503).

Ejemplo

T1503
Referencia del producto
-
25G
Tamaño del envase/cantidad

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705578-5MG-PW

PL860-CGA/SHF-1EA

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1000309185

introducir como 1.000309185)

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Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch».

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Sonam Dolma et al.
Cancer cell, 3(3), 285-296 (2003-04-05)
We used synthetic lethal high-throughput screening to interrogate 23,550 compounds for their ability to kill engineered tumorigenic cells but not their isogenic normal cell counterparts. We identified known and novel compounds with genotype-selective activity, including doxorubicin, daunorubicin, mitoxantrone, camptothecin, sangivamycin
The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells
Wang D, et al.
Biochemical and Biophysical Research Communications, 503(3), 1689-1695 (2018)
Ding Wang et al.
Biochemical and biophysical research communications, 480(4), 602-607 (2016-10-30)
Dopamine is a neurotransmitter that has many functions in the nervous and immune systems. Ferroptosis is a non-apoptotic form of regulated cell death that is involved in cancer and neurodegenerative diseases. However, the role of dopamine in ferroptosis remains unidentified.
Ferroptosis is an autophagic cell death process
Gao M, et al.
Cell research, 26(9), 1021-1021 (2016)
Nicholas Yagoda et al.
Nature, 447(7146), 864-868 (2007-06-15)
Therapeutics that discriminate between the genetic makeup of normal cells and tumour cells are valuable for treating and understanding cancer. Small molecules with oncogene-selective lethality may reveal novel functions of oncoproteins and enable the creation of more selective drugs. Here

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Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

Discover Bioactive Small Molecules for Cell Cycle Research

n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

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