E7781

Erastin

≥98% (HPLC)

• Synonym(s): 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
• Empirical Formula (Hill Notation): C₃₀H₃₁ClN₄O₄
• CAS Number: 571203-78-6
• Molecular Weight: 547.04
• Número MDL: MFCD09837984
• ID de la sustancia en PubChem: 329799073

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• SMILES string: CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5
• InChI: 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
• InChI key: BKQFRNYHFIQEKN-UHFFFAOYSA-N
• Gene Information: human ... hRas(3265) ; mouse ... hRas(15461) ; rat ... hRas(293621)

Description

Descripción general

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc^-.

Aplicación

Erastin has been used:

• as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
• to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
• to induce ferroptosis of muscle-derived cell lines

Envase

1, 5 mg in glass bottle

Acciones bioquímicas o fisiológicas

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Código de clase de almacenamiento: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges