Merck
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G1251

Sigma-Aldrich

L-Glutamic acid

ReagentPlus®, ≥99% (HPLC)

Sinónimos:
Glu, (S)-2-Aminopentanedioic acid
Fórmula lineal:
HO2CCH2CH2CH(NH2)CO2H
Número de CAS:
Peso molecular:
147.13
Beilstein:
1723801
Número de EC:
Número MDL:
eCl@ss:
32160406
ID de la sustancia en PubChem:
NACRES:
NA.26

línea de producto

ReagentPlus®

ensayo

≥99% (HPLC)

formulario

powder

technique(s)

microbiological culture: suitable

color

white to off-white

mp

205 °C (dec.) (lit.)

solubilidad

1 M HCl: soluble 100 mg/mL

densidad

1.54 g/cm3 at 20 °C

trazas de catión

C: 40.4-41.2%
N: 9.2-9.8%

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

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Aplicación

L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.

Envase

1 kg in poly bottle
100, 500 g in poly bottle
5 kg in poly drum

Acciones bioquímicas o fisiológicas

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Información legal

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

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Certificado de origen

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
DeBerardinis RJ
Cell Metabolism, 7(1), 11-20 (2008)
Cristina Giaroni et al.
European journal of pharmacology, 476(1-2), 63-69 (2003-09-13)
Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described
Glutamic acid, twenty years later.
Garattini S
The Journal of Nutrition, 130, 901S-909S (2000)
Mixed carbon source utilization of meat-spoiling Pseudomonas fragi 72 in relation to oxygen limitation and carbon dioxide inhibition.
Molin G.
Applied and Environmental Microbiology, 49(6), 1442-1447 (1985)
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