G1251

L-Glutamic acid

ReagentPlus^®, ≥99% (HPLC)

• Synonym(s): (S)-2-Aminopentanedioic acid, Glu
• Linear Formula: HO₂CCH₂CH₂CH(NH₂)CO₂H
• CAS Number: 56-86-0
• Molecular Weight: 147.13
• Beilstein: 1723801
• Número de EC: 200-293-7
• Número MDL: MFCD00002634
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24895052
• NACRES: NA.26

Properties

• Nivel de calidad: 200
• Línea del producto: ReagentPlus^®
• ensayo: ≥99% (HPLC)
• formulario: powder
• technique(s): microbiological culture: suitable
• color: white to off-white
• mp: 205 °C (dec.) (lit.)
• solubilidad: 1 M HCl: soluble 100 mg/mL
• densidad: 1.54 g/cm³ at 20 °C
• trazas de catión: C: 40.4-41.2%; N: 9.2-9.8%
• SMILES string: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChI key: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Gene Information: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Description

Aplicación

L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.

Acciones bioquímicas o fisiológicas

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Información legal

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)