Merck
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G3416

Sigma-Aldrich

5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate

solid, ≥98% (HPLC)

Synonym(s):
GNTI
Empirical Formula (Hill Notation):
C27H29N5O3 · 2C2HF3O2 · xH2O
CAS Number:
Molecular Weight:
699.60 (anhydrous basis)
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

solid

solubilidad

H2O: 30 mg/mL

temp. de almacenamiento

2-8°C

Gene Information

human ... OPRK1(4986)

Aplicación

5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
  • to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation[1]
  • to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)[2]
  • to validate its inhibitory actions on Akt kinase activities[3]

Envase

5 mg in glass bottle

Acciones bioquímicas o fisiológicas

5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative[4] and a selective κ opiate receptor antagonist.[1][5] It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.[5]

Características y beneficios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información legal

Sold under US Patent No. 6,500,824.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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