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β-Glucuronidase from Helix pomatia

Type HP-2, aqueous solution, ≥100,000 units/mL

β-D-Glucuronide glucuronosohydrolase
CAS Number:
Enzyme Commission number:
Número MDL:

origen biológico

Helix pomatia

Nivel de calidad


Type HP-2


aqueous solution

specific activity

≥100,000 units/mL

secondary activity

≤7,500 units/mL sulfatase

enviado en

wet ice

temp. de almacenamiento


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Descripción general

β-Glucuronidase Type H-2 from Helix pomatia is a crude solution of enzymes derived from the digestive juices of the Roman snail. β-glucuronidases derived from mollusks often contain sulfatase activity. Both activities are useful in the hydrolysis of metabolites for toxicology and biomarker analysis. For a broader look at our β-Glucuronidase product line and their uses see our page about Drug Metabolite Analysis


  • Sample preparation for LC/MS through digestion of glucuronide conjugated compounds for biomarker and toxicology research.
  • Removal of glucuronide conjugates such as for the preparation of Baicalein.­
New Technical Article Comparing Performance of Different Enzymes
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine


1, 2, 5, 10, 25, 100 mL

Acciones bioquímicas o fisiológicas

Endogenous beta-glucuronidase is a lysosomal enzyme involved in digestion of glucuronide-modified catabolites.
Microbial beta-glucuronidase found in microbiota can cause re-absorption of metabolites by hydrolysis of glucuronide conjugates of xenobiotic and endobiotic metabolites.
Used for the hydrolysis of glucuronide conjugates in urinary metabolite analysis

Características y beneficios

  • pH optima 4.0 - 5.0.
  • Sulfatase pH optima 6.2
  • Low Sulfatase activity (<7,500 units/mL).
  • Ammonium Sulfate suspension.
  • Mollusk-derived beta-glucuronidase.
  • Useful for acidic hydrolysis of glucuronides in low pH samples.


Many β-glucuronidases derived from mollusks also contain sulfatase activity.

Ligadura / enlace

Similar to G0876, but produced by Sigma.

Definición de unidad

One Sigma or modified Fishman unit will liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37 °C at pH 5.0 (30 min assay).
Sulfatase Unit Definition: One unit of sulfatase will hydrolyze 1.0 μmole p-nitrocatechol sulfate per hr at pH 5.0 at 37 °C.

Forma física

Aqueous solution in ~1.0 M ammonium sulfate with 3 mM sodium azide as preservative.


Health hazard

Palabra de señalización


Frases de peligro

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

10 - Combustible liquids



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Certificate of Origin

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