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H7041

Sigma-Aldrich

Interleukin-2 human

IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

Sinónimos:
T-cell growth factor, Interleukin-2
Número MDL:
NACRES:
NA.77

Nivel de calidad

100

origen biológico

human

recombinante

expressed in HEK 293 cells

formulario

lyophilized powder

potencia

≤5.0 ng/mL ED50

calidad

endotoxin tested

mol peso

dimer 15 kDa (glycosylated)

envase

pkg of 5X10 μg
pkg of 10 μg
pkg of 100 μg

technique(s)

cell culture | mammalian: suitable

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Gene Information

human ... IL2(3558)

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Descripción general

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Aplicación

Interleukin-2 human has been used to culture peripheral blood mononuclear cells (PBMC). It has been used to activate effector cell (PBMC) and to study antibody-dependent cell-mediated cytotoxicity.

Envase

10 μg in poly bottle

Acciones bioquímicas o fisiológicas

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the formation and essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. IL-2 mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Nota de preparación

Human Interleukin-2 (IL-2) expressed in human HEK 293 cells is a glycosylated monomer with a molecular mass of 15 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Nota de análisis

The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Functional incompatibility between the generic NF-? motif and a subtype-specific Sp1III element drives the formation of HIV-1 subtype C viral promoter
Verma A, et al.
Journal of Virology, JVI-00308 (2016)
N-glycan engineering of a plant-produced anti-CD20-hIL-2 immunocytokine significantly enhances its effector functions
Marusic C, et al,
Biotechnology and Bioengineering, 115(3), 565-576 (2018)
Interleukin 2, 37-37 (2012)
Loss of immune tolerance to IL-2 in type 1 diabetes
Perol L, et al.
Nature Communications, 7, 13027-13027 (2016)
Association of- 330 interleukin-2 gene polymorphism with oral cancer
Singh PK, et al.
The Indian Journal of Medical Research, 146(6), 730-730 (2017)

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