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Anti-PNPO antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Anti-Pyridoxamine-phosphate oxidase, Anti-Pyridoxine-5'-phosphate oxidase
Atlas de proteínas humanas número:

origen biológico


Nivel de calidad




forma del anticuerpo

affinity isolated antibody

antibody product type

primary antibodies



línea de producto

Prestige Antibodies® Powered by Atlas Antibodies


buffered aqueous glycerol solution

species reactivity


validación mejorada

Learn more about Antibody Enhanced Validation


immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

secuencia del inmunógeno


Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento


Gene Information

human ... PNPO(55163)

Categorías relacionadas

Descripción general

The gene PNPO (pyridoxamine 5′-phosphate oxidase) is mapped to human chromosome 17q21. The gene encodes a flavin mononucleotide-dependent oxidase.


Pyridoxine-5′-phosphate oxidase recombinant protein epitope signature tag (PrEST)


All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Acciones bioquímicas o fisiológicas

PNPO (pyridoxamine 5′-phosphate oxidase) is required for the formation of pyridoxal 5′-phosphate (PLP) from pyridoxine (and its phosphate, PNP (pyridoxine 5′-phosphate) and glucoside) and from pyridoxamine (and its phosphate, PMP (pyridoxamine 5′-phosphate)). It is also important for the regeneration of PLP by recycling PMP. PLP is a cofactor, which participates in the homocysteine metabolism and formation of neurotransmitters. PNPO mutations are associated with neonatal onset seizures.

Características y beneficios

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST75550.

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Información legal

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

10 - Combustible liquids



Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

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Certificado de origen

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Philippa B Mills et al.
Brain : a journal of neurology, 137(Pt 5), 1350-1360 (2014-03-20)
The first described patients with pyridox(am)ine 5'-phosphate oxidase deficiency all had neonatal onset seizures that did not respond to treatment with pyridoxine but responded to treatment with pyridoxal 5'-phosphate. Our data suggest, however, that the clinical spectrum of pyridox(am)ine 5'-phosphate
Michael Steffens et al.
Human molecular genetics, 21(24), 5359-5372 (2012-09-06)
Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% and account for 20-30% of all epilepsies. Despite their high heritability of 80%, the genetic factors predisposing to GGEs remain elusive. To identify susceptibility variants shared across common GGE syndromes
Hongwei Song et al.
Schizophrenia research, 97(1-3), 264-270 (2007-09-14)
Accumulating evidence suggests that both homocysteine metabolism and monoaminergic neurotransmitter systems are important in schizophrenia pathology. We hypothesized that the gene PNPO (pyridoxine 5'-phosphatase oxidase gene) might be a candidate for susceptibility to schizophrenia because PNPO encodes pyridoxamine 5'-phosphate oxidase
Anja Fux et al.
Cell chemical biology, 26(10), 1461-1468 (2019-08-27)
Pyridoxal 5'-phosphate (PLP) is a versatile cofactor that catalyzes a plethora of chemical transformations within a cell. Although many human PLP-dependent enzymes (PLP-DEs) with crucial physiological and pathological roles are known, a global method enabling their cellular profiling is lacking.

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