I1149

Iodoacetamide

BioUltra

• Synonym(s): 2-Iodoacetamide, Monoiodoacetamide, alpha-Iodoacetamide
• Linear Formula: ICH₂CONH₂
• CAS Number: 144-48-9
• Molecular Weight: 184.96
• Beilstein: 1739080
• Número de EC: 205-630-1
• Número MDL: MFCD00008028
• ID de la sustancia en PubChem: 24278486
• NACRES: NA.77

Properties

• origen biológico: synthetic (organic)
• Nivel de calidad: 300
• Línea del producto: BioUltra
• ensayo: ≥99% (NMR)
• formulario: powder
• impurezas: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• mp: 92-95 °C (lit.)
• solubilidad: H₂O: 0.5 M, clear, colorless
• trazas de anión: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• trazas de catión: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• temp. de almacenamiento: 2-8°C
• SMILES string: NC(=O)CI
• InChI: 1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
• InChI key: PGLTVOMIXTUURA-UHFFFAOYSA-N

Description

Aplicación

Iodoacetamide has been used:

• in protein digestion for proteomic analysis
• to alkylate protein samples
• in the denaturation of cow′s milk allergens, β-lactoglobulin (BLG) and α-lactalbumin (ALA)

Envase

5, 25, 100 g in glass bottle

Acciones bioquímicas o fisiológicas

Iodoacetamide (IAA) is used to inhibit glycolysis due to its ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). IAA is used to investigate the role of cysteine residues in enzyme catalysis and the brain cell transport process. It can react with low molecular weight thiol compounds like mercaptoethanol and glutathione. IAN may also block enzymes like bromelain, cathepsin C, clostripain, and carboxypeptidase P.

Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.

Safety Information

• pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301 - H317 - H334 - H413
• Consejos de prudencia: P261 - P264 - P273 - P280 - P301 + P310 - P302 + P352
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges