L7134

Sigma-Aldrich

Luteinizing hormone releasing hormone human acetate salt

≥98% (HPLC), powder

Sinónimos:
LH-RH, Gonadotropin releasing hormone, Gonadoliberin
Empirical Formula (Hill Notation):
C55H75N17O13
Número de CAS:
Peso molecular:
1182.29
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (HPLC)

form

powder

mol wt

Mr 1182.33

storage temp.

−20°C

SMILES string

CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O

InChI

1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1

InChI key

QOVPLTBEZAJSHY-VIRDRFNDSA-N

Gene Information

human ... GNRH1(2796)

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Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Application

Luteinizing hormone releasing hormone human acetate salt has been used:
  • for synchronization of the ovulations
  • for pre-absorption of the anti-GnRH antibody in staining procedures
  • to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Components

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Other Notes

free peptide
Lyophilized from 0.5% acetic acid

pictograms

Health hazard

signalword

Danger

hcodes

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

ERa and GnRH co-localize in the hypothalamic neurons of the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Pablo Ignacio
Journal of Molecular Histology (2017)
Nicholas A Levis et al.
Ecology and evolution, 5(7), 1405-1411 (2015-04-22)
Phenotypic plasticity is commonplace, and plasticity theory predicts that organisms should often evolve mechanisms to detect and respond to environmental cues that accurately predict future environmental conditions. Here, we test this prediction in tadpoles of spadefoot toads, Spea multiplicata. These...
Histological characterization of gonadotropin-releasing hormone
(GnRH) in the hypothalamus of the South American plains
vizcacha (Lagostomus maximus)
Veronica, et.la
Journal of Molecular Histology (2011)
Developmental Programming: Impact of Prenatal Exposure to Bisphenol-A and Methoxychlor on Steroid Feedbacks in Sheep
Bachir Abi Salloum
Toxicology and Applied Pharmacology (2013)
S Shacham et al.
Annales d'endocrinologie, 60(2), 79-88 (1999-08-24)
The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase C beta. Inositol...

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