Merck

M4528

Sigma-Aldrich

Monoclonal Anti-MAP1b antibody produced in mouse

clone AA6, ascites fluid

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Sinónimos:
Anti-MAP1.2, Anti-MAP1X, Anti-MAP5
Número MDL:
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

antibody product type

primary antibodies

clon

AA6, monoclonal

contiene

15 mM sodium azide

species reactivity

human, feline, bovine, hamster, chicken, mouse, rat

technique(s)

microarray: suitable
western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation

isotipo

IgG1

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP1B(4131)
mouse ... Mtap1b(17755)
rat ... Map1b(29456)

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Este artículo
M4278M4403M1406
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

clone

AA6, monoclonal

clone

HM-1, monoclonal

clone

HM-2, monoclonal

clone

AP-20, monoclonal

species reactivity

human, feline, bovine, hamster, chicken, mouse, rat

species reactivity

mouse, rat

species reactivity

rat, chicken, human, mouse, bovine, quail

species reactivity

Xenopus, mouse, quail, human, bovine, rat, aquatic salamander

technique(s)

microarray: suitable, western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation

technique(s)

immunohistochemistry (frozen sections): suitable, microarray: suitable, western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: 1:1,000 using a fresh total rat brain extract or an enriched microtubule protein preparation

technique(s)

immunocytochemistry: suitable, western blot: 1:500 using rat brain enriched microtubule protein preparation or rat cerebral cortex extract

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Descripción general

MAP1b is a microtubule associated protein that interacts with actin filaments. MAP1b regulates microtubule stabilization and the development of axons. It may also act as a scaffolding protein Addition of antibody to microtubule proteins before polymerization in immunoassays results in abnormally short (but otherwise morphologically normal) microtubules. Immunohistochemical staining of brain tissue with the product shows selective labeling of dendritic trees throughout the brain. Monoclonal Anti-MAP1b does not react with tubulin of other microtubule associated proteins.
Monoclonal Anti-MAP1b (MAP5) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Microtubule-associated protein (MAP1B) is the major microtubule associated protein in developing brain which changes its expression during development. In the new born rat brain, it is a major component of microtubules but in the adult its level is ten-fold lower.

Especificidad

Monoclonal Anti-MAP1b antibody is specific for MAP1b in humans, mice, rats, bovines, cats, hamsters and chickens. The antibody does not cross-react with other MAPs or tubulin. Addition of the antibody to microtubule proteins before polymerization results in abnormally short (but otherwise morphologically normal) microtubules. In immunohistochemical staining of brain tissue, the antibody shows selective labeling of neurons with stronger staining of axons, dendrites and cell bodies.

Inmunógeno

rat brain microtubule-associated proteins (MAPs)

Aplicación

Monoclonal Anti-MAP1b antibody produced in mouse has been used in:
  • immunohistochemistry
  • immunostaining
  • fluorescence microscopy

Acciones bioquímicas o fisiológicas

Microtubule-associated protein (MAP1B) is the first MAP to appear in growing axons during development as it is present from the first emergence of the nascent axon from the cell body. Monoclonal Anti-MAP1b may be used to study MAP expression and cytological localization both in tissues and cell lines, under different developmental and environmental circumstances.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Association of microtubule-associated protein (MAP1B) with growing axons in cultured hippocampal neurons
Fischer I and Romano CG
Molecular and Cellular Neurosciences, 2(1), 39-51 (1991)
Human mesenchymal precursor cells (Stro-1+) from spinal cord injury patients improve functional recovery and tissue sparing in an acute spinal cord injury rat model
Hodgetts SI, et al.
Cell Transplantation, 22(3), 393-412 (2013)
Carolina Montenegro-Venegas et al.
Molecular biology of the cell, 21(20), 3518-3528 (2010-08-20)
Cultured neurons obtained from MAP1B-deficient mice have a delay in axon outgrowth and a reduced rate of axonal elongation compared with neurons from wild-type mice. Here we show that MAP1B deficiency results in a significant decrease in Rac1 and cdc42
Masamitsu Shimazawa et al.
The Journal of pharmacology and experimental therapeutics, 332(2), 380-387 (2009-11-17)
We examined whether ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), a new orally available calpain inhibitor, might reduce retinal cell death in vivo and/or in vitro. Retinal cell damage was induced in vivo in mice by intravitreal injection of N-methyl-d-aspartate (NMDA), and
Human pluripotent stem cells and derived neuroprogenitors display differential degrees of susceptibility to BH3 mimetics ABT-263, WEHI-539 and ABT-199
Garcia CP, et al.
Testing, 11(3), e0152607-e0152607 (2016)

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