M7273

Sigma-Aldrich

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit

whole antiserum

MDL number:

biological source

rabbit

Quality Level

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

mammals

application(s)

western blot: 1:200

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

General description

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).

Specificity

Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin.

Immunogen

heat stable MAPs prepared from bovine brain.

Application

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:
  • immunofluorescent labelling
  • immunohistochemistry
  • immunoprecipitation
  • immunofluorescence staining
  • western blotting

Biochem/physiol Actions

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis

Certificado de origen

The MAP2/Tau family of microtubule-associated proteins
Dehmelt L, et al.
Genome Biology, 6(1), 1-10 (2005)
Dynamic Instability of Microtubules Assembled from Microtubule-Associated Protein-Free Tubulin: Neither Variability of Growth and Shortening Rates nor ?Rescue? Requires Microtubule-Associated Proteins
Billger MA, et al.
Biochemistry, 35(42), 13656-13663 (1996)
J H Holstein et al.
British journal of pharmacology, 154(5), 1055-1062 (2008-05-06)
The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF...
Increased Phosphorylation of Ca/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation
Fukunaga K, et al.
Test, 270(11), 6119-6124 (1995)
Suzana Angelica Silva Lustosa et al.
TheScientificWorldJournal, 2014, 102541-102541 (2014-04-17)
Colorectal cancer dissemination depends on extracellular matrix genes related to remodeling and degradation of the matrix structure. This investigation intended to evaluate the association between FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 gene and protein expression levels in tumor tissue with...

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