M8421
Monoclonal Anti-Myosin (Skeletal, Slow) antibody produced in mouse
clone NOQ7.5.4D, ascites fluid
Sinónimos:
Anti-CMD1S, Anti-CMH1, Anti-MPD1, Anti-MYHCB, Anti-SPMD, Anti-SPMM
About This Item
Productos recomendados
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
NOQ7.5.4D, monoclonal
contains
15 mM sodium azide
species reactivity
sheep, rat, bovine, hamster, pig, canine, feline, goat, chicken, mouse, rabbit, human, guinea pig
packaging
antibody small pack of 25 μL
technique(s)
electron microscopy: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:4,000 using protease-digested, sections of rabbit tongue
indirect ELISA: suitable
radioimmunoassay: suitable
western blot: 1:5,000 using extract of rat or rabbit tongue
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYH7(4625)
mouse ... Myh7(140781)
rat ... Myh7(29557)
General description
Monoclonal Anti-Myosin (Skeletal, Slow) (mouse IgG1 isotype) is derived from the NOQ7.5.4D hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Myosin, purified from myofibrils isolated from human skeletal muscle, was used as the immunogen.1-3. The isotype is determined by a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents, Catalog Number ISO2.
Specificity
Immunogen
Application
Monoclonal Anti-Myosin (Skeletal, Slow) antibody has been used in the detection of Myosin 7 using:
- light microscopy
- immunofluorescence staining
- immunoblotting
- ELISA
- solid-phase RIA
- immunohistology (frozen, formalin-fixed, paraffin-embedded and methacarn-fixed paraffin-embedded tissue sections)
- immunoelectronmicroscopy
Biochem/physiol Actions
Transient expression of different myosin isoforms occurs during fetal growth and development. Mutations in myosin 7 is associated with laing distal myopathy (LDM). Myosin 7 gene mutations results in muscular dystrophy diseases like scapuloperoneal myopathy. Mutations leads to storage of myosin protein aggregates in muscle, leading to myosin storage myopathy. Mutations in MYH7 is also associated with hypertrophic cardiomyopathy and in heart malformation disease called ebstein anomaly.
Physical form
Storage and Stability
Disclaimer
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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