Merck

M9281

Sigma-Aldrich

3-Methyladenine

autophagy inhibitor

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Sinónimos:
3-MA, 6-Amino-3-methylpurine
Empirical Formula (Hill Notation):
C6H7N5
Número de CAS:
Peso molecular:
149.15
Beilstein:
146087
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.51

origen biológico

synthetic (organic)

Nivel de calidad

Análisis

≥99% (HPLC)

formulario

powder

mp

~300 °C (dec.) (lit.)

solubilidad

DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow

SMILES string

Cn1cnc(N)c2ncnc12

InChI

1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChI key

FSASIHFSFGAIJM-UHFFFAOYSA-N

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Este artículo
666548E4267G6779
3-Methyladenine autophagy inhibitor

Sigma-Aldrich

M9281

3-Methyladenine

-
7-Methyladenine 97%

Sigma-Aldrich

666548

7-Methyladenine

-
9-Ethylguanine

Sigma-Aldrich

E4267

9-Ethylguanine

-
Guanine BioUltra

Sigma-Aldrich

G6779

Guanine

Premium Grade
assay

≥99% (HPLC)

assay

97%

assay

≥98%

assay

≥99% (HPLC)

form

powder

form

solid

form

powder

form

powder

mp

~300 °C (dec.) (lit.)

mp

346-350 °C

mp

-

mp

>300 °C (lit.)

solubility

DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow

solubility

-

solubility

1 M NaOH: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

solubility

1 M NaOH: 0.1 M, clear, colorless to faintly yellow

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

Aplicación

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
3-Methyladenine has been used as an autophagy inhibitor:
  • to determine the expressions of autophagy-related genes (Beclin 1, light chain 3 (LC3) and p62) using the transfected human bone marrow mesenchymal stem cells (BM-MSCs)
  • with cisplatin to study the inhibition of autophagy influenced cisplatin-induced apoptosis in A2780cp cells
  • to study the interplay between colistin-induced autophagy and apoptosis

Standard for detection of nucleic acid methylation during carcinogenesis.

Acciones bioquímicas o fisiológicas

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

Nota de preparación

This product is soluble in DMF (10 mg/mL; may require gentle heating). It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/mL with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA may be prepared in DMSO at 100 mM.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable


Certificates of Analysis (COA)

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Las referencias de los producto se combinan con los tamaños de envase y las cantidades cuando se muestran en la página web, por ejemplo: T1503-25G. Asegúrese de introducir el número de producto ÚNICAMENTE en el campo del Número de producto (ejemplo: T1503).

Ejemplo

T1503
Referencia del producto
-
25G
Tamaño del envase/cantidad

Otros ejemplos

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

introducir como 1.000309185)

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Journal of dairy science, 102(9), 8264-8272 (2019-07-01)
Staphylococcus aureus is an important pathogen causing chronic and subclinical mastitis of cows. Autophagy is an important regulatory mechanism that participates in the elimination of invading pathogenic organisms. Here, we hypothesize that autophagy is involved in the process of Staph.
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Atherosclerosis is a progressive, chronic inflammation in arterial walls. Long noncoding RNAs (lncRNAs) participate in inflammation, but the exact mechanism in atherosclerosis is unclear. Our microarray analyses revealed that the levels of lncRNA-FA2H-2 were significantly decreased by oxidized low-density lipoprotein
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Journal of biochemical and molecular toxicology, 33(8), e22348-e22348 (2019-05-09)
Golgi S-nitro-N-acetylpenicillamine receptor complex 1 (GS28) has been implicated in Golgi vesicle transport. We examined the role of GS28 and its molecular mechanisms in sodium nitroprusside (SNP)-induced cell death using GS28 siRNA (siGS28)-transfected HeLa cells. Significant inhibition of cytotoxicity was

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