M9570

Sigma-Aldrich

Anti-Matrix Metalloproteinase-9 antibody produced in goat

affinity isolated antibody

Sinónimos:
Mmp-9 Antibody, Anti-MMP-9, MMP-9 Antibody - Anti-Matrix Metalloproteinase-9 antibody produced in goat
MDL number:
NACRES:
NA.41

Quality Level

biological source

goat

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

application(s)

immunohistochemistry: 5-15 μg/mL using cells or tissues
immunoprecipitation (IP): 25 μg/mL using conditioned media of transfected NSO cells
western blot: 0.25 μg/mL

conjugate

unconjugated

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Mmp9(17395)

General description

Matrix metalloproteinase-9 (MMP-9) is a pro-inflammatory, zinc-dependent proteinase which is also known as 92kDa gelatinase. It is produced by various cells like granulocytes and mononuclear cells. The gene encoding it is localized on human chromosome 20q11.2-q13.1.

Specificity

This antibody recognizes pro and active mouse MMP-9. Immunoblotting and ELISA applications show an ~10% cross-reactivity with recombinant human MMP-9.

Immunogen

purified, NSO-derived, recombinant mouse matrix metalloproteinase-9.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)

Biochem/physiol Actions

Matrix metalloproteinase-9 (MMP-9) has been studied as a biomarker of nervous tissue inflammation in multiple sclerosis (MS).

Target description

Matrix Metalloproteinase-9 encodes an enzyme that degrades type IV and V collagens.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Yuta Morisaki et al.
Scientific reports, 6, 27354-27354 (2016-06-07)
Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast fatigue-resistant (FR) or slow (S) MNs. The reason for this selective vulnerability remains enigmatic. We report...
Beate Fisslthaler et al.
International journal of molecular sciences, 20(12) (2019-06-30)
The AMP-activated protein kinase (AMPK) is an energy sensing kinase that is activated by a drop in cellular ATP levels. Although several studies have addressed the role of the AMPKα1 subunit in monocytes and macrophages, little is known about the...
S Shekar Dukkipati et al.
The Journal of physiology, 596(9), 1723-1745 (2018-03-05)
Motoneuron soma size is a largely plastic property that is altered during amyotrophic lateral sclerosis (ALS) progression. We report evidence of systematic spinal motoneuron soma size plasticity in mutant SOD1-G93A mice at various disease stages and across sexes, spinal regions...
Xiaoli Zhang et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 1115-1123 (2015-04-22)
The role of matrix metalloproteinase 9 (MMP-9) polymorphisms in breast cancer risk remains unclear. The purpose of this study was to evaluate the association between MMP-9 variants and breast cancer susceptibility. Case-control studies were searched on electronic databases to retrieve...
Senem Maral et al.
Medicine, 94(16), e732-e732 (2015-04-24)
Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have potential to degrade...

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