N1537

Sigma-Aldrich

NU7026

≥98% (HPLC), solid

Sinónimos:
2-(Morpholin-4-yl)-benzo[h]chromen-4-one
Empirical Formula (Hill Notation):
C17H15NO3
Número de CAS:
Peso molecular:
281.31
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

color

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

Application

NU7026 has been used:
  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2
Spryszynska S, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)
Rachel E Doherty et al.
Cancers, 11(9) (2019-09-05)
Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)...
Hideaki Ogiwara et al.
PloS one, 6(12), e28756-e28756 (2011-12-24)
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation. In vitro reconstitution studies have indicated that NHEJ of incompatible DNA ends...
Weiwei Li et al.
Mutation research, 779, 112-123 (2015-07-24)
Although studies have shown that cadmium (Cd) interfered with DNA damage repair (DDR), whether Cd could affect non-homologous end joining (NHEJ) repair remains elusive. To further understand the effect of Cd on DDR, we used X-ray irradiation of Hela cells...
Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells
Rahal ON, et al.
Cancer Biology & Therapy, 17(11), 1139-1148 (2016)

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