P6249

p53 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

• NACRES: NA.25

Properties

• origen biológico: human
• Nivel de calidad: 200
• recombinante: expressed in E. coli
• ensayo: ≥75% (SDS-PAGE)
• formulario: buffered aqueous glycerol solution
• Nº de acceso UniProt: P04637
• application(s): genomic analysis
• enviado en: wet ice
• temp. de almacenamiento: −20°C
• Gene Information: human ... TP53(7157)

Description

Descripción general

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

Envase

50 μg

Aplicación

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Acciones bioquímicas o fisiológicas

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

Propiedades físicas

GST-tagged, full-length human p53

Safety Information

• Código de clase de almacenamiento: 10 - Combustible liquids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable