P8386

Phenylbutazone

• Sinónimos: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
• Empirical Formula (Hill Notation): C₁₉H₂₀N₂O₂
• Número de CAS: 50-33-9
• Peso molecular: 308.37
• Número de EC: 200-029-0
• Número MDL: MFCD00005500
• ID de la sustancia en PubChem: 24277729
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• origen biológico: synthetic (organic)
• ensayo: ≥98% (HPLC)
• formulario: powder
• mp: 106-108 °C (lit.)
• solubilidad: ethanol: 50 mg/mL, clear, colorless to light yellow
• SMILES string: CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
• InChI: 1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
• InChI key: VYMDGNCVAMGZFE-UHFFFAOYSA-N
• Gene Information: human ... CYP2C9(1559) , PTGIS(5740) , PTGS1(5742) , PTGS2(5743)

Descripción

Aplicación

Phenylbutazone has been used:

• as a hepatotoxin in transgenic zebrafish line (LiPan) hepatotoxin assay
• as a standard in high-performance liquid chromatography-ultraviolet (HPLC-UV) method
• as an anti-inflammatory compound in hen′s egg chorioallantoic membrane test (HET-CAM assay)

Envase

25, 100, 500 g in poly bottle

Acciones bioquímicas o fisiológicas

Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles.

Sustratos

Non-steroidal anti-inflammatory compound; inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.

Información de seguridad

• pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301 - H312 + H332 - H315 - H319 - H335
• Consejos de prudencia: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves