Merck
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P9255

Sigma-Aldrich

Pyridoxal 5′-phosphate hydrate

≥98%

Sinónimos:
3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Pyridoxal phosphate, PLP, Pyridoxal 5-phosphate, Codecarboxylase
Empirical Formula (Hill Notation):
C8H10NO6P · xH2O
Número de CAS:
Peso molecular:
247.14 (anhydrous basis)
Beilstein:
234749
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.79

Nivel de calidad

200

origen biológico

synthetic (organic)

ensayo

≥98%

formulario

powder

technique(s)

HPLC: suitable

color

beige
off-white to yellow

mp

140-143 °C

temp. de almacenamiento

−20°C

SMILES string

CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O

InChI

1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChI key

NGVDGCNFYWLIFO-UHFFFAOYSA-N

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Descripción general

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.

Aplicación

Pyridoxal 5′-phosphate hydrate has also been used:
  • as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)
  • in D-amino acid transaminase reaction(10)
  • as a cofactor for L-glutamic acid decarboxylase

Envase

1, 5, 25 g in poly bottle

Acciones bioquímicas o fisiológicas

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

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Certificado de origen

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Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae
Muhlenhoff U, et al.
Test, 279(35), 36906-36915 (2004)
Structure of the mitochondrial aminolevulinic acid synthase, a key heme biosynthetic enzyme
Brown BL, et al.
Structure, 26(4), 580-589 (2018)
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies
Yamada T, et al.
Biochim. Biophys. Acta Gen. Subj., 1780(5), 809-818 (2008)
Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5?-phosphate biosynthesis
Belitsky BR
Journal of Bacteriology, 186(4), 1191-1196 (2004)
Preparation, Stimulation and Other Uses of Adult Rat Brain Synaptosomes
Modi J, et al.
Bio-protocol, 7(24) (2017)

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