PZ0162

PD 0325901

≥98% (HPLC)

• Synonym(s): N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
• Empirical Formula (Hill Notation): C₁₆H₁₄F₃IN₂O₄
• CAS Number: 391210-10-9
• Molecular Weight: 482.19
• Número MDL: MFCD08435926
• ID de la sustancia en PubChem: 329823743

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
• manufacturer/tradename: Pfizer^®
• color: white to off-white
• solubilidad: DMSO: 20 mg/mL, clear
• emisor: Pfizer
• temp. de almacenamiento: 2-8°C
• SMILES string: FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F
• InChI: 1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
• InChI key: SUDAHWBOROXANE-SECBINFHSA-N
• Gene Information: human ... MAP2K1(5604) , MAP2K2(5605)

Description

Aplicación

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Acciones bioquímicas o fisiológicas

PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma and melanoma tumor progression.

PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Características y beneficios

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Otras notas

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información legal

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety Information

• pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301 - H373 - H413
• Consejos de prudencia: P260 - P264 - P273 - P301 + P310 - P314 - P405
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable