Merck
All Photos(1)

PZ0335

Sigma-Aldrich

CP724714

≥98% (HPLC)

Synonym(s):
(E)-2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide, 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide, CP-724,714, CP-724714
Empirical Formula (Hill Notation):
C27H27N5O3
CAS Number:
Molecular Weight:
469.53
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

manufacturer/tradename

Pfizer®

color

white to beige

solubilidad

DMSO: 20 mg/mL, clear

emisor

Pfizer

temp. de almacenamiento

room temp

SMILES string

COCC(NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)C2=C1)=O

InChI

1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+

InChI key

LLVZBTWPGQVVLW-SNAWJCMRSA-N

Gene Information

human ... ERBB2(2064)

Related Categories

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.

Otras notas

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Información legal

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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