Merck
All Photos(2)

R0395

Sigma-Aldrich

Rapamycin from Streptomyces hygroscopicus

≥95% (HPLC), powder

Synonym(s):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
Empirical Formula (Hill Notation):
C51H79NO13
CAS Number:
Molecular Weight:
914.17
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

300

ensayo

≥95% (HPLC)

formulario

powder

color

off-white

solubilidad

ethanol: 2 mM
DMSO: soluble

espectro de actividad antibiótica

fungi
yeast

Modo de acción

enzyme | inhibits
protein synthesis | interferes

emisor

Pfizer

temp. de almacenamiento

−20°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

Gene Information

human ... FKBP1A(2280)

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Descripción general

Chemical structure: macrolide

Envase

1 mg in glass bottle

Acciones bioquímicas o fisiológicas

A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

Características y beneficios

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Carc. 2 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 2

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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More Documents

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