Merck
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R8781

Sigma-Aldrich

Rapamycin

Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

Synonym(s):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
Empirical Formula (Hill Notation):
C51H79NO13
Molecular Weight:
914.17
Número de EC:
NACRES:
NA.77

origen biológico

Streptomyces hygroscopicus

Nivel de calidad

300

presión de vapor

0.56 hPa ( 20 °C)

esterilidad

0.2 μm filtered

ensayo

≥95% (HPLC)

formulario

solution

temp. de autoignición

301 °C

concentración

2.5 mg/mL in DMSO (2.74 mM)

color

colorless to yellow

espectro de actividad antibiótica

fungi
yeast

Modo de acción

enzyme | inhibits

emisor

Pfizer

temp. de almacenamiento

−20°C

Acciones bioquímicas o fisiológicas

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

Características y beneficios

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Envase

200uL

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

188.6 °F - closed cup

Punto de inflamabilidad C

87 °C - closed cup

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificate of Analysis

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Certificate of Origin

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