S4317

SB 431542 hydrate

≥98% (HPLC), powder

• Synonym(s): 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• Empirical Formula (Hill Notation): C₂₂H₁₆N₄O₃ · xH₂O
• CAS Number: 301836-41-9
• Molecular Weight: 384.39 (anhydrous basis)
• Número MDL: MFCD11045982
• ID de la sustancia en PubChem: 24724609
• NACRES: NA.77

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• solubilidad: DMSO: soluble 10 mg/mL; H₂O: insoluble
• emisor: GlaxoSmithKline
• temp. de almacenamiento: −20°C
• SMILES string: O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
• InChI: 1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
• InChI key: WQUIJVKNPYBZOF-UHFFFAOYSA-N

Description

Aplicación

SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells. It was used to study the role of TGF-β signaling in modulation of extracellular matrix and myoblast differentiation.

Envase

5 mg in glass bottle

Acciones bioquímicas o fisiológicas

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.

Características y beneficios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información legal

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)